购物车
- 全部删除
- 您的购物车当前为空
Diphenyleneiodonium chloride (DPI) 是 NADPH 氧化酶抑制剂,也是 TRPA1激活剂,EC50为 1 - 3 μM 。它选择性抑制胞内活性氧。
Diphenyleneiodonium chloride (DPI) 是 NADPH 氧化酶抑制剂,也是 TRPA1激活剂,EC50为 1 - 3 μM 。它选择性抑制胞内活性氧。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 179 | 现货 | |
5 mg | ¥ 398 | 现货 | |
10 mg | ¥ 638 | 现货 | |
25 mg | ¥ 1,160 | 现货 | |
50 mg | ¥ 1,890 | 现货 | |
100 mg | ¥ 3,230 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 452 | 现货 |
产品描述 | Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity. |
靶点活性 | iNOS:50 nM , eNOS:0.3 µM |
体外活性 | Diphenyleneiodonium chloride (DPIC), an NADPH/NADH oxidase inhibitor, as possessing potent antimicrobial activity against non-tuberculous mycobacteria.?DPIC exhibited concentration-dependent bactericidal activity against M. fortuitum and synergized with amikacin, ceftriaxone, ceftazidime and meropenem[1]. |
细胞实验 | Whole-cell growth inhibition assays were used to screen and identify novel inhibitors. The hit compounds(Diphenyleneiodonium chloride) were tested for cytotoxicity against Vero cells to determine the selectivity index, and time-kill kinetics were determined against Mycobacterium fortuitum. The compound's ability to synergize with amikacin, ceftriaxone, ceftazidime and meropenem was determined using fractional inhibitory concentration indexes followed by its ability to decimate mycobacterial infections ex vivo[1]. |
别名 | 二苯基氯化碘盐, DPI |
分子量 | 314.55 |
分子式 | C12H8ClI |
CAS No. | 4673-26-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 6 mg/mL (19.07 mM) | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
|
版权所有©2015-2024 TargetMol Chemicals Inc.保留所有权利.